Showing posts with label Alzheimer. Show all posts
Showing posts with label Alzheimer. Show all posts

Thursday, July 24, 2014

How Sugar Harms Your Brain Health and Drives Alzheimer’s Epidemic

English: PET scan of a human brain with Alzhei...
English: PET scan of a human brain with Alzheimer's disease (Photo credit: Wikipedia)
By Dr. Mercola
Alzheimer's disease, a severe form of dementia, affects an estimated 5.2 million Americans, according to 2013 statistics.1
One in nine seniors over the age of 65 has Alzheimer's, and the disease is now thought to be the third leading cause of death in the US, right behind heart disease and cancer.
A growing body of research suggests there's a powerful connection between your diet and your risk of developing Alzheimer's disease, via similar pathways that cause type 2 diabetes.
Contrary to popular belief, your brain does not require glucose, and actually functions better burning alternative fuels, especially ketones, which your body makes in response to digesting healthy fats.
According to some experts, such as Dr. Ron Rosedale, Alzheimer's and other brain disorders may in large part be caused by the constant burning of glucose for fuel by your brain.
Alzheimer's disease was tentatively dubbed "type 3 diabetes" in early 2005 when researchers discovered that in addition to your pancreas, your brain alsoproduces insulin, and this brain insulin is necessary for the survival of brain cells.

Sugar Damages Brain Structure and Function

In your brain, insulin helps with neuron glucose-uptake and the regulation of neurotransmitters, such as acetylcholine, which are crucial for memory and learning. This is why reducing the level of insulin in your brain impairs your cognition.
Research2 has also shown that type 2 diabetics lose more brain volume with age than expected—particularly gray matter. This kind of brain atrophy is yet another contributing factor for dementia.
Studies have found that people with lower levels of insulin and insulin receptors in their brain often have Alzheimer's disease. But according to recent research published in the journal Neurology,3 sugar and other carbohydrates can disrupt your brain function even if you're not diabetic or have any signs of dementia.
To test their theory, they evaluated short- and long-term glucose markers in 141 healthy, non-diabetic, non-demented seniors. Memory tests and brain imaging were administered to assess their brain function and the actual structure of their hippocampus. As reported by Scientific American:4
"Higher levels on both glucose measures were associated with worse memory, as well as a smaller hippocampus and compromised hippocampal structure.
The researchers also found that the structural changes partially accounted for the statistical link between glucose and memory. According to study co-author Agnes Flöel, a neurologist at Charité, the results 'provide further evidence that glucose might directly contribute to hippocampal atrophy.'"
The findings suggest that even if you're not diabetic or insulin resistant (and about 80 percent of Americans fall into the latter category), sugar consumption can still disrupt your memory.
Long-term, it can contribute to the shrinking of your hippocampus, which is a hallmark symptom of Alzheimer's disease. (Your hippocampus is involved with the formation, organization, and storage of memories.)
The authors of the study suggest that "strategies aimed at lowering glucose levels even in the normal range may beneficially influence cognition in the older population."

'Normal' Blood Sugar Levels May Still Be High Enough to Cause Problems

Normally, a fasting blood sugar level between 100-125 mg/dl is diagnosed as a pre-diabetic state. A fasting blood sugar level of 90-100 is considered "normal." But in addition to the featured research, other studies have also found that brain atrophy occurs even in this "normal" blood sugar range.
Neurologist Dr. David Perlmutter, MD insists that being very strict in limiting your consumption of sugar and non-vegetable carbs is one of THE most important steps you can take to prevent Alzheimer's disease for this very reason.
He cites research from the Mayo Clinic, which found that diets rich in carbohydrates are associated with an 89 percent increased risk for dementia. Meanwhile, high-fat diets are associated with a 44 percent reduced risk.

Sugar Lobby Threatens Organizations and Buries Science on Health Effects

Compelling research shows that your brain has great plasticity, which you controlthrough your diet and lifestyle choices. Unfortunately, the American public has been grossly brainwashed by the sugar and processed food industries into believing that sugar is a perfectly reasonable "nutrient" that belongs in a healthy diet.  
Without accurate information, it's certainly more difficult to make health-affirming choices. Newsweek5 recently ran an article revealing just how far the sugar industry will go to defend its market share:
"According to a new report6 from the Center for Science and Democracy... industry groups representing companies that sell sweeteners, like the Sugar Association and the Corn Refiners Association... have poured millions of dollars into countering science that indicates negative health consequences of eating their products.
For example, when a University of Southern California study from 2013 found that the actual high fructose corn syrup content in sodas 'varied significantly' from the sugar content disclosed on soda labels, the Corn Refiners Association considered paying for its own counter research.
A consultant suggested that the counter research should only be published if the results aligned with their goal of disputing the USC study: 'If for any reason the results confirm [the University of Southern California study], we can just bury the data,' the consultant wrote, according to the report."
According to the Center for Science report, the Sugar Association even threatened the director general of the World Health Organization (WHO). WHO had published a paper on sugar, recommending a 10 percent limit on added sugars, stating that added sugars "threaten the nutritional quality of diets."
The Sugar Association shot off a letter to the director general, warning him that, unless WHO withdrew the study, the Sugar Association would persuade the US Congress to withdraw the WHO's federal funding. The following year, when WHO published its global health strategy on diet and health, there was no mention of the offending sugar study.

The Sugar Lobby Deserves Blame for Fueling Chronic Disease Epidemics

Indeed, despite overwhelming evidence showing that sugar, and processed fructose in particular, is at the heart of our burgeoning obesity and chronic disease epidemics, the sugar lobby has been so successful in its efforts to thwart the impact of such evidence that there's still no consensus among our regulatory agencies as to the "factual" dangers of sugar...
According to Centers for Disease Control and Prevention (CDC) data,7 13 percent of the average American's diet is sugar. In the UK, a recently published report8 by the Scientific Advisory Committee on Nutrition (SACN) recommends limiting your added sugar intake to five percent, in order to avoid obesity and type 2 diabetes. They calculate this to be the equivalent of 25 grams of sugar (5-6 teaspoons) per day for women, and 35 grams (7-8 teaspoons) for men.
This matches my own recommendations for healthy, non-insulin resistant individuals—with one key difference. I recommend restricting sugar/fructose consumption to 25 grams from ALL sources, not just added sugar. This includes limiting your non-vegetable carbohydrates as well. Crazy enough, the Scientific Advisory Committee on Nutrition still recommends you get 50 percent of your daily energy intake in the form of starchy carbohydrates, which will undoubtedly and significantly raise your risk of insulin resistance. If you're insulin/leptin resistant, diabetic, overweight, or have high blood pressure, heart disease, or cancer, I recommend restricting your sugar/fructose consumption to a maximum of 15 grams per day from all sources, until your insulin/leptin resistance has been resolved.

Dietary Guidelines for Maintaining Healthy Brain Function and Avoiding Alzheimer's Disease

It's becoming increasingly clear that the same pathological process that leads to insulin resistance and type 2 diabetes may also hold true for your brain. As you over-indulge on sugar and grains, your brain becomes overwhelmed by the consistently high levels of glucose and insulin that blunts its insulin signaling, leading to impairments in your thinking and memory abilities, eventually causing permanent brain damage.
Additionally, when your liver is busy processing fructose (which your liver turns into fat), it severely hampers its ability to makecholesterol, an essential building block of your brain that is crucial for optimal brain function. Indeed, mounting evidence supports the notion that significantly reducing fructose consumption is a very important step for preventing Alzheimer's disease
Because of the very limited treatments, and no available cure as of yet, you're really left with just one solid solution, and that is to prevent Alzheimer's from happening to you in the first place. As explained by neurologist Dr. David Perlmutter, Alzheimer's is a disease predicated primarily on lifestyle choices; the two main culprits being excessive sugar and gluten consumption.
Another major factor is the development and increased consumption of genetically engineered (GE) grains, which are now pervasive in most processed foods sold in the US. The beauty of following my optimized nutrition plan is that it helps prevent and treat virtually ALL chronic degenerative diseases, including Alzheimer's. Dr. Perlmutter's book, Grain Brain, also provides powerful arguments for eliminating grains from your diet, particularly if you want to protect the health of your brain. In terms of your diet, the following suggestions may be among the most important for Alzheimer's prevention:
  • Avoid sugar and refined fructose. Ideally, you'll want to keep your total sugar and fructose below 25 grams per day, or as low as 15 grams per day if you have insulin resistance or any related disorders. In one recent animal study, a junk food diet high in sugar resulted in impaired memory after just one week!9 Place recognition, specifically, was adversely affected.
  • As a general rule, you'll want to keep your fasting insulin levels below 3, and this is indirectly related to fructose, as it will clearly lead to insulin resistance. However, other sugars (sucrose is 50 percent fructose by weight), grains, and lack of exercise are also important factors. Lowering insulin will also help lower leptin levels which is another factor for Alzheimer's.
  • Avoid gluten and casein (primarily wheat and pasteurized dairy, but not dairy fat, such as butter). Research shows that your blood-brain barrier, the barrier that keeps things out of your brain where they don't belong, is negatively affected by gluten. Gluten also makes your gut more permeable, which allows proteins to get into your bloodstream, where they don't belong. That then sensitizes your immune system and promotes inflammation and autoimmunity, both of which play a role in the development of Alzheimer's.
  • Eat a nutritious diet, rich in folate, such as the one described in my nutrition plan. Vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day. Avoid supplements like folic acid, which is the inferior synthetic version of folate.
  • Increase consumption of all healthful fats, including animal-based omega-3. Beneficial health-promoting fats that your brain needs for optimal function include organic butter from raw milk, clarified butter called ghee, organic grass fed raw butter, olives, organic virgin olive oil and coconut oil, nuts like pecans and macadamia, free-range eggs, wild Alaskan salmon, and avocado.
  • Contrary to popular belief, the ideal fuel for your brain is not glucose but ketones. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy. The medium-chain triglycerides (MCTs) found in coconut oil are a great source of ketone bodies, because coconut oil is about 66 percent MCTs. In 2010, I published Dr. Mary Newport's theory that coconut oil might offer profound benefits in the fight against Alzheimer's disease. She has since launched one of the first clinical trials of its kind to test this theory.
    Also make sure you're getting enough animal-based omega-3 fats, such as krill oil. (I recommend avoiding most fish because, although fish is naturally high in omega-3, most fish are now severely contaminated with mercury.) High intake of the omega-3 fats EPA and DHA help by preventing cell damage caused by Alzheimer's disease, thereby slowing down its progression, and lowering your risk of developing the disorder.
  • Optimize your gut flora by regularly eating fermented foods or taking a high-potency and high-quality probiotic supplement
  • Eat blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer's and other neurological diseases. 

Other Helpful Dietary Tips and Valuable Supplements

Another helpful tip is to reduce your overall calorie consumption, and/or intermittently fast. As mentioned above, ketones are mobilized when you replace carbs with coconut oil and other sources of healthy fats. A one-day fast can help your body to "reset" itself, and start to burn fat instead of sugar. As part of a healthy lifestyle, I prefer an intermittent fasting schedule that simply calls for limiting your eating to a narrower window of time each day. By restricting your eating to a 6-8 hour window, you effectively fast 16-18 hours each day. To learn more about intermittent fasting, please see this previous article.
Also be aware that when it comes to cholesterol levels and Alzheimer's, lower is NOT better. Quite the contrary. According to Dr. Perlmutter, research shows that elderly individuals with the lowest cholesterol levels have the highest risk for Alzheimer's. They also have the highest risk for dying. As he says, the war on cholesterol is fundamentally inappropriate and harmful.
Finally, there's a short list of supplement recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to take special note of the following natural dietary agents. These four natural foods/supplements have good science behind them, in terms of preventing age-related cognitive changes:
  1. Gingko bilobaMany scientific studies have found that Ginkgo biloba has positive effects for dementia. A 1997 study fromJAMA showed clear evidence that Ginkgo improves cognitive performance and social functioning for those suffering from dementia. Another 2006 study found Ginkgo as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer's type dementia. A 2010 meta-analysis also found Ginkgo biloba to be effective for a variety of types of dementia.
  2. Alpha lipoic acid (ALA): ALA has been shown to help stabilize cognitive functions among Alzheimer's patients and may slow the progression of the disease.
  3. Vitamin B12: A small Finnish study published in the journal Neurology10 found thatpeople who consume foods rich in B12 may reduce their risk of Alzheimer's in their later years. For each unit increase in the marker of vitamin B12 the risk of developing Alzheimer's was reduced by two percent. Remember sublingual methylcobalamin may be your best bet here.

Lifestyle Strategies That Can Help Ward off Alzheimer's Disease

Lifestyle choices such as getting regular sun exposure and exercise, along with avoiding toxins, are also important factors when it comes to maintaining optimal brain health. Here are several of my lifestyle suggestions:
  • Optimize your vitamin D levels with safe sun exposure. Strong links between low levels of vitamin D in Alzheimer's patients and poor outcomes on cognitive tests have been revealed. Researchers believe that optimal vitamin D levels may enhance the amount of important chemicals in your brain and protect brain cells by increasing the effectiveness of the glial cells in nursing damaged neurons back to health.
  • Vitamin D may also exert some of its beneficial effects on Alzheimer's through its anti-inflammatory and immune-boosting properties. Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation that is also associated with Alzheimer's.
  • Exercise regularly. It's been suggested that exercise can trigger a change in the way the amyloid precursor protein is metabolized,11 thus, slowing down the onset and progression of Alzheimer's. Exercise also increases levels of the protein PGC-1alpha. Research has also shown that people with Alzheimer's have less PGC-1alpha in their brains12 and cells that contain more of the protein produce less of the toxic amyloid protein associated with Alzheimer's. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
  • Avoid and eliminate mercury from your body. Dental amalgam fillings, which are 50 percent mercury by weight, are one of the major sources of heavy metal toxicity. However, you should be healthy prior to having them removed. Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed.
  • Avoid aluminum, such as antiperspirants, non-stick cookware, vaccine adjuvants, etc.
  • Avoid flu vaccinations as most contain both mercury and aluminum, well-known neurotoxic and immunotoxic agents.
  • Avoid anticholinergics and statin drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.
  • Statin drugs are particularly problematic because they suppress the synthesis of cholesterol, deplete your brain of coenzyme Q10 and neurotransmitter precursors, and prevent adequate delivery of essential fatty acids and fat-soluble antioxidants to your brain by inhibiting the production of the indispensable carrier biomolecule known as low-density lipoprotein.
  • Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer's. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer's disease.

 http://articles.mercola.com/sites/articles/archive/2014/07/24/sugar-brain-function.aspx

Friday, June 27, 2014

Supporting Evidence for Aspartame-Alzheimer’s Link Emerges

English: PET scan of a human brain with Alzhei...
English: PET scan of a human brain with Alzheimer's disease (Photo credit: Wikipedia)
         By Dr. Mercola
Most public health agencies and nutritionists in the United States still recommend no- or low-calorie artificial sweeteners as an acceptable, and even preferred, alternative to sugar. This flawed advice can have very serious repercussions for those who follow it.
Artificial sweeteners of all kinds have been found to wreak havoc with your health in a number of different ways. Aspartame, which is perhaps the worst of the bunch, has a long list of studies indicating its harmful effects, ranging from brain damage to pre-term delivery.
Aspartame is also the number one source of side effect complaints to the US Food and Drug Administration (FDA), with over 10,000 complaints filed and over 91 documented symptoms related to its consumption.
Most recently, studies are also starting to confirm lingering suspicions that artificial sweeteners like aspartame may play a role in the development of Alzheimer's disease, a serious form of dementia that is now thought to kill over half a million Americans each year.
The key mechanism of harm appears to be methanol toxicity—a much-ignored problem associated with aspartame in particular.
In a previous interview, toxicology expert Dr. Woodrow Monte (author of the bookWhile Science Sleeps: A Sweetener Kills1), explained the links between aspartame and methanol toxicity and the formation of formaldehyde. In light of the latest research, this interview is more relevant than ever, which is why I included it again.

Methanol Toxicity Leads to Persistent Alzheimer's Symptoms

A recently published two-part paper2, 3 highlights what Dr. Monte has been saying for many years now—that methanol acts differently in animals and humans. In this case, the researchers also discovered changes in effect between mice and rhesus monkeys.
Methanol-fed mice presented with partial "Alzheimer's disease-like symptoms," while rhesus monkeys fed a 3% methanol solution developed persistent pathological changes related to the development of Alzheimer's. According to the authors:
"A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's disease (AD) pathology has provided a new impetus to investigate the chronic effects of methanol exposure.
This paper expands this investigation to the non-human primate, rhesus macaque... [M]ethanol feeding led to persistent memory decline in the monkeys that lasted 6 months beyond the feeding regimen...
Most notably, the presence of amyloid plaque formations in the monkeys highlighted a marked difference in animal systems used in AD investigations, suggesting that the innate defenses in mice against methanol toxicity may have limited previous investigations into AD pathology.
Nonetheless, these findings support a growing body of evidence that links methanol and its metabolite formaldehyde to AD pathology." [Emphasis mine]

The Link Between Aspartame and Methanol Toxicity

The artificial sweetener industry (and makers of artificially sweetened products) has fervently claimed that aspartame is harmless, and that there's "no biological explanation" for the health problems reported by so many after consuming aspartame.
But as explained by Dr. Monte, there is indeed a biological and scientific explanation for aspartame's pathway of harm, and as the latest research suggests, it's related to the effects of methanol and formaldehyde, both of which are extremely toxic.
Aspartame is primarily made up of aspartic acid and phenylalanine—the latter of which has been synthetically modified to carry a methyl group. This is what provides the majority of the sweetness. That phenylalanine methyl bond, called a methyl ester, is very weak, allowing the methyl group on the phenylalanine to easily break off and form methanol.
You may have heard the claim that aspartame is harmless because methanol is also found in fruits and vegetables. However, in these whole foods the methanol is firmly bonded to pectin, which allows it to be safely passed through your digestive tract. This is not the case for the methanol created by aspartame. There, it's not bonded to anything that can help eliminate it from your body. That's problem number one...
Problem number two relates to the fact that humans are the only mammals who are NOT equipped with a protective biological mechanism that breaks down methanol into harmless formic acid. This is why animal testing of aspartame does not fully apply to humans.
According to Dr. Monte, the fact that methyl alcohol is metabolized differently in humans compared to other animals has been known since 1940. And according to the featured paper, rhesus monkeys do not appear to have the same defenses against methanol toxicity as mice do. This basically negates much of the animal research that has been used to "prove" aspartame's safety.

Methanol Acts as a Trojan Horse in Your Body

As explained by Dr. Monte, in humans, methanol ends up acting as a Trojan horse, allowing toxic formaldehyde to wreak havoc in some of your most sensitive areas, such as your brain. Here's how it works: both animals and humans have small structures called peroxisomes in each cell. There are a couple of hundred in every cell of your body, which are designed to detoxify a variety of chemicals. Peroxisome contains catalase, which help detoxify methanol.
Your cells also contain alcohol dehydrogenase (ADH), which converts methanol to formaldehydeOther chemicals in the peroxisome in turn convert the formaldehyde to formic acid, which is harmless—but this last step occurs only in animals. Human peroxisomes cannot convert the toxic formaldehyde into harmless formic acid.
Certain locations in your body, particularly in the lining of your blood vessels, and in your brain, are loaded with ADH that converts methanol to formaldehyde. But since there's no catalase present, the formaldehyde does not get converted into harmless formic acid. As a result, the formaldehyde is free to do enormous amounts of damage in your tissues.
Symptoms of methanol poisoning include: headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances, weakness, vertigo, chills, memory lapses, numbness, and shooting pains in the extremities, behavioral disturbances, and neuritis. The most well known problems from methanol poisoning are vision problems including misty vision, progressive contraction of visual fields, blurring of vision, obscuration of vision, retinal damage, and blindness. Formaldehyde, in turn, is a known carcinogen that causes retinal damage, interferes with DNA replication, and may cause birth defects.

Processed Foods Are Also High in Methanol

As I've discussed in previous articles, processed foods should be avoided as a proactive Alzheimer's prevention strategy. In his book, Grain Brain, neurologist Dr. Perlmutter reveals how the toxic activity of sugar and carbohydrates in your diet promote Alzheimer's disease. But we can also add methanol to the list of reasons for avoiding processed foods. Not only do many processed foods contain artificial sweeteners, but when fruits and vegetables are canned, for example, the methanol becomes liberated from the pectin.
At room temperature, it only takes one month for 10 percent of the methanol to be released. After about six months, virtually all of the methanol is liberated. Dr. Monte is convinced that methanol and the subsequent conversion to formaldehyde from certain processed foods (see listing below), as well as all foods containing aspartame, are a major culprit in a variety of diseases, especially multiple sclerosis (MS).
Again, methanol can slip through your blood brain barrier, and your brain is one of the areas where you find alcohol dehydrogenase, which converts methyl alcohol to formaldehyde. This causes the destruction of myelin basic protein, which is one of the triggers for MS. Demyelination also plays a role in the development of Alzheimer's and several other brain-related diseases. According to Dr. Monte:
"We know that methyl alcohol is known to be a demyelinating agent... [T]he symptoms associated with the demyelination... are identical between multiple sclerosis, and methanol poisoning, and people who consume aspartame."
He believes many diseases can be prevented if we start avoiding methanol from all sources, and he even offers a methanol-free diet on his website.4 Items to avoid include:
CigarettesTomato sauces, unless first simmered at least 3 hours, no lid on pan
Diet foods and drinks with aspartameSmoked food of any kind, particularly fish and meat
Fruit and vegetable products and their juices in bottles, cans, or pouchesChewing gum, as most chewing gum in the USA contains aspartame
Jellies, jams, and marmalades not made fresh and kept refrigeratedSlivovitz and other fruit schnapps
Black currant and tomato juice products, fresh or processedOverly ripe or near rotting fruits or vegetables

The Neurotoxic Properties of Splenda

Another popular artificial sweetener is sucralose, sold under the brand name Splenda. Sucralose is a synthetic chemical created in a five-step patented process, in which three chlorine molecules are added to one sucrose (sugar) molecule. Some will argue that natural foods also contain chloride, which is true. However, in natural foods, the chloride is connected with ionic bonds that easily dissociate when ingested. In Splenda, they're in a covalent bond that does not dissociate.
And, since your body has no enzymes to break down this covalently bound chloride, harm can ensue... The reason why your body has no enzymes for this task is because, in nature, there are NO covalent chloride bonds to organic compounds—they only exist in synthetic, man-made form. Aside from Splenda, other examples of synthetic covalently bound chloride compounds include DDT, PCBs, and Agent Orange.
Previous research indicates that about 15 percent of sucralose is absorbed into your digestive system, and ultimately stored in your body fat. A 2008 animal study5 found that Splenda reduced the amount of beneficial intestinal bacteria by 50 percent, increased the intestinal pH level, and affected a glycoprotein that can have crucial health effects, particularly if you're on certain medications.
More recent research6 detailing Splenda's oxidative effects, suggests the sweetener may have neurotoxic properties, which doesn't surprise me in the least. The researchers, who assessed the effects of sucralose on water fleas, concluded that: "exposure to sucralose may induce neurological and oxidative mechanisms with potentially important consequences for animal behavior and physiology." As reported by GreenMedInfo.com:7
"Like so many novel patented chemicals released onto the market without adequate pre-approval safety studies, we do not know if this preliminary toxicological research will be applicable to human exposures. In fact, there are only 318 study citations on this chemical in existence since it first began to be researched in the 70's. This most recent study is the first in existence to look at its effect on the enzyme acetylcholinesterase, which is found in all animals.
This information deficit is all the more remarkable when you consider there are over 7,000 published studies in existence on either turmeric or its primary polyphenol curcumin, which is still not readily administered by the conventional medical establishment mostly due to 'safety concerns,' despite what the voluminous positive data on its relevance to over 600 health conditions indicates."

FDA Approval Means Little When It Comes to Ascertaining Safety

As previously noted by Dr. Janet Hull,8 many tend to excuse the negative health effects of aspartame simply because it has received the stamp of approval by the FDA. But as discussed in her article, "Abusing the FDA Approval Process,"9 the FDA requires that the industry do its own researchand actually places the burden of proof on the company making the product. Rarely is the industry research reviewed by independent researchers. Should you still be confused on this issue, thinking that the buck somehow stops at the FDA, FDA spokesman Theresa Eisenman recently clarified who is ultimately responsible for making sure a food product is safe, stating that:10 "Manufacturers are responsible for ensuring that their food products are safe and lawful..."
But what company would really make a serious effort to find problems with the very products they want to capitalize on? Despite this illogical premise, the FDA trusts corporations to be honest in their research and evaluations. How likely do you think it is that this "honor system" will actually ensure that each product released to market is safe?
When it comes to artificial sweeteners, aspartame in particular, there's no doubt in my mind that the system has protected industry profits at consumers' expense. And we've not seen the last of it. Despite mounting evidence showing that artificial sweeteners as a group have adverse health effects, the FDA has just approved yet another artificial sweetener called Advantame,11, 12, 13 concocted from a combination of aspartame and vanillin, an artificial vanilla flavor.
Being 20,000 times sweeter than refined sugar, Advantame is the sweetest artificial sweetener so far. To put this into perspective, aspartame, sucralose, and saccharine range from 200 to 700 times sweeter than sugar. Also, as reported by the LA Times:14
"Like aspartame, advantame contains phenylalanine, which is metabolized with difficulty by people with a rare genetic disorder, phenylketonuria. But because of its intense sweetness, advantame would be used at much lower volumes than is asparatame. As a result, the FDA has declared that it can be safely consumed by those with phenylketonuria."

Having a Hard Time Giving Up Artificial Sweeteners?

When you consume artificial sweeteners, your brain actually craves more calories because your body receives no satisfaction on a cellular level by the sugar imposter. This can contribute to not only overeating and weight gain, but also an addiction to artificial sweeteners. To break free, I recommend addressing any emotional component of your food cravings using a tool such as theEmotional Freedom Technique (EFT). A version of EFT specifically geared toward combating sugar cravings is called Turbo Tapping. The video below with EFT practitioner Julie Schiffman also demonstrates how to use EFT to fight food cravings of all kinds.

If you still have cravings after trying EFT or Turbo Tapping, you may need to make some changes to your diet. My free nutrition plan can help you do this in a step-by-step fashion. As for safer sweetener options, you could use stevia or Luo Han, both of which are safe natural sweeteners. That said, if you struggle with high blood pressure, high cholesterol, diabetes or extra weight, then you have insulin sensitivity issues and would likely benefit from avoiding ALL sweeteners.
Last but not least, if you experience side effects from aspartame or any other artificial sweetener, please report it to the FDA (if you live in the United States) without delay. It's easy to make a report — just go to the FDA Consumer Complaint Coordinator page, find the phone number for your state, and make a call reporting your reaction.