Showing posts with label Gut flora. Show all posts
Showing posts with label Gut flora. Show all posts

Wednesday, September 11, 2013

Dangers to Infants You Need to Be Aware of

By Dr. Mercola
Babies are born at considerable risk nowadays. Toxic exposures and lack of nutrition and beneficial microbes in utero and after birth can contribute to a wide variety of health problems. Here, I will cover four commonly overlooked infant dangers:
  • Poor gut health
  • Flame retardant chemicals
  • Insufficient vitamin D
  • Exposure to genetically modified organisms (GMOs)

Gut Bacteria May Influence Your Baby’s Growth

Research has demonstrated that microorganisms in the human gastrointestinal tract form an intricate, living fabric of natural controls affecting body weight, energy, and nutrition.
Most recently, a Norwegian study published in the journal PLoS Computational Biology1 found that the types of bacteria present in an infant’s digestive system influences the child’s growth.2
Your child’s digestive tract is quickly populated with a variety of bacteria originating from mother's vaginal tract (if delivered via vaginal birth), breast milk (if breastfed), and other sources, such as infant formula.
Toxic exposures and certain drugs can also alter your child’s microflora. Examples include pesticides like glyphosate, and antibiotics—both of which can decimate populations of beneficial gut microbes.
Understanding how infants’ microbiota develops over time is important in order to devise strategies to change it for the better; thereby benefiting children’s long-term health. Similar research is being done to determine the impact of different microbiota on adult health and disease through the American Gut Project.
In this study, they found that the presence of Bacteroides in male babies at 30 days of age was significantly associated with reduced growth. In contrast, the presence of E. coli species between the age of four days and one month was linked with normal growth in both boys and girls. According to the authors:
"We have created a new way of looking at the development of gut microbiota [the body's microbial ecosystem] over time and relating this development to health outcomes.
After applying our new method, we found an indication that the composition of early life gut microbiota may be associated with how fast or slow babies grow in early life although there is also the possibility that factors early in life affect both gut microbiota and how fast the baby grows."

Your Baby's Gut Flora Impacts Far More Than Just Growth

The health implications of variations in gut bacteria acquired from birth is exactly what Dr. Natasha Campbell-McBride's research sheds light upon. Her research shows there's a profound dynamic interaction between your gut, your brain, and your immune system, starting from birth.

She has developed what might be one of the most profoundly important treatment strategies for a wide range of neurological, psychological, and autoimmune disorders—all of which are heavily influenced by your gut health.
I believe her Gut and Psychology Syndrome, and Gut and Physiology Syndrome (GAPS) Nutritional program is vitally important for MOST people, as the majority of people have such poor gut health due to poor diet and toxic exposures, but it's particularly crucial for pregnant women and young children.
Children who are born with severely damaged gut flora are not only more susceptible to disease; they're also more susceptible to vaccine damage, which may help explain why some children develop symptoms of autism after receiving one or more childhood vaccinations.
It's important to understand that the gut flora a child acquires during vaginal birth is dependent on the mother's gut flora.
So if mother's microflora is abnormal, the child's will be abnormal as well. GAPS can manifest as a conglomerate of symptoms that can fit the diagnosis of both physical disorders and brain disorders, including autism, attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), dyslexia, dyspraxia, or obsessive-compulsive disorder, just to name a few possibilities.
Digestive issues, asthma, allergies, skin problems and autoimmune disorders are also common outgrowths of GAPS, as it can present itself either psychologically or physiologically.
If you've taken antibiotics or birth control pills, if you eat a lot of processed or sugary foods, or if you were bottle-fed as a baby—all of these can impact the makeup of bacteria and microbes in your gut, which are then transferred to your child.
For instance, we now know that breastfed babies develop entirely different gut flora compared to bottle-fed babies. Infant formula never was, and never will be, a healthy replacement for breast milk, for a number of reasons -- altered gut flora being one of them (and this applies whether the infant formula contains genetically engineered (GE) ingredients or not, although GE ingredients may be far worse).
Maintaining optimal gut flora, and 'reseeding' your gut with fermented foods and probiotics when you're taking an antibiotic, may be one of the most important steps you can take to improve your health, and this is particularly important if you’re planning to become pregnant. If you aren't eating fermented foods, you most likely need to supplement with a probiotic on a regular basis, especially if you're eating a lot of processed foods.

Parental Saliva May Have Beneficial Effect on Baby’s Immune System, Cutting Allergy Risk

Infant growth is just one of many aspects affected by the composition of bacteria in your body. Another recent study published in the journal Pediatrics3 found that parents who clean off their child’s pacifier by sucking on it may be inadvertently reducing their child's risk of developing allergies4, 5. This appears to be a side effect of your oral bacteria affecting your child’s gut bacteria.
According to the authors:
"Exposure of the infant to parental saliva might accelerate development of a complex oral/pharyngeal microbiota that, similar to a complex gut microbiota, might beneficially affect tolerogenic handling of antigens by the oral/pharyngeal lymphoid tissues. Moreover, oral bacteria are swallowed and hence also affect the composition of the microbiota in the small intestine, which may in turn regulate tolerance development in the gut."
Other studies have similarly shown that your child’s microbiota may influence his or her risk of developing allergies as a result of leaky gut syndrome. Leaky gut is a condition that occurs due to the development of gaps between the cells (enterocytes) that make up the membrane lining your intestinal wall. These tiny gaps allow substances such as undigested food, bacteria and metabolic wastes that should be confined to your digestive tract to escape into your bloodstream -- hence the term leaky gut syndrome.
Once the integrity of your intestinal lining is compromised, and there is a flow of toxic substances "leaking out" into your bloodstream, your body experiences significant increases in inflammation. Besides being associated with inflammatory bowel diseases like Crohn's and ulcerative colitis, or celiac disease, leaky gut can also be a contributing factor to allergies.
Interestingly, the study also concluded that vaginal delivery and parental pacifier sucking were independently associated with a reduced likelihood of developing eczema. Prevalence of this skin condition was lowest—20 percent—among infants covered by both factors, and highest (54 percent) among those born via cesarean birth and whose parents did not clean their pacifiers by sucking on it.
"Thus, vaginal delivery, which is a source for transfer of a complex microbiota from mother to infant and parent and infant sharing of a pacifier might both lead to microbial stimulation, with beneficial effects on allergy development," the researchers wrote.

Parents, Beware of Toxic Flame-Retardant Chemicals

Next we get into toxins... Here, you could fill an entire library with information, but some toxins are more prevalent and/or more dangerous than others. For example, preliminary research findings6, 7 suggest that children exposed to polybrominated diphenyl ethers (PBDEs) in utero are at increased risk for hyperactivity and lower IQ. PBDEs are fire-retardant chemicals that have been in use for decades in items like carpeting, upholstery, mattresses, baby strollers and electronics, just to name a few.
Animal tests have shown that the chemicals disrupt the endocrine system, and because their chemical structure resembles thyroid hormone, they may affect thyroid function. In children, thyroid hormone is important for proper growth and development, especially brain development.
The researchers measured PBDE levels in the blood of 309 pregnant women, and their children were later evaluated through intelligence and behavior tests once a year until the age of five. They discovered that PBDE exposure in the womb was associated with hyperactivity between the ages of two and five, and with lower IQ scores at age five. A tenfold increase in PBDE exposure during pregnancy was related to about a four-point IQ deficit in five-year-old children. Previous research8 has also linked PBDE exposure in utero to reductions in IQ, as well as deficits in fine motor function and attention. According to study author Dr. Aimin Chen, assistant professor in the department of environmental health at the University of Cincinnati College of Medicine:
"In animal studies, PBDEs can disrupt thyroid hormone and cause hyperactivity and learning problems. Our study adds to several other human studies to highlight the need to reduce exposure to PBDEs in pregnant women... Because PBDEs exist in the home and office environment as they are contained in old furniture, carpet pads, foams and electronics, the study raises further concern about their toxicity in developing children.”

 http://articles.mercola.com/sites/articles/archive/2013/09/11/baby-health-dangers.aspx  Link back to Mercola.com where the story originated.  More on this topic at the link above.

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Thursday, July 25, 2013

Probiotics, The New Prozac?

Probiotic Drinks
Probiotic Drinks (Photo credit: Jepster)
By Dr. Mercola
While many think of their brain as the organ in charge of their mental health, yourgut may actually play a far more significant role.

The big picture many of us understand is one of a microbial world that we just happen to be living in. Our actions interfere with these microbes, and they in turn respond having more effects to our individual health as well as the entire environment.

There is some truth to the old expression, having 'dirt for brains'.  The microbes in our soil, on our plants, in our stomachs are all a result of our actions.  Antibiotics, herbicides, vaccines, and pesticides, and the tens of thousands of synthetic chemicals we've created all have impacts and result in reactions from these microbes.
Mounting research indicates that problems in your gut can directly impact your mental health, leading to issues like anxiety and depression.
The gut-brain connection is well-recognized as a basic tenet of physiology and medicine, so this isn't all that surprising, even though it's often overlooked. There's also a wealth of evidence showing intestinal involvement in a variety of neurological diseases.
With this in mind, it should also be crystal clear that nourishing your gut flora is extremely important, because in a very real sense you have two brains, one inside your skull and one in your gut, and each needs its own vital nourishment. A recent article1 titled “Are Probiotics the New Prozac?” reviews some of the most recent supporting evidence.

Probiotics Alter Brain Function, Study Finds

The featured proof-of-concept study, conducted by researchers at UCLA, found that probiotics (beneficial bacteria) actually altered participants' brain function. The study2 enlisted 36 women between the ages of 18 and 55 who were divided into three groups:
  • The treatment group ate yogurt containing several probiotics thought to have a beneficial impact on intestinal health, twice a day for one month
  • Another group ate a “sham” product that looked and tasted like the yogurt but contained no probiotics
  • Control group ate no product at all
Before and after the four-week study, participants underwent functional magnetic resonance imaging (fMRI) scans, both while in a state of rest, and in response to an “emotion-recognition task.”
For the latter, the women were shown a series of pictures of people with angry or frightened faces, which they had to match to other faces showing the same emotions.
“This task, designed to measure the engagement of affective and cognitive brain regions in response to a visual stimulus, was chosen because previous research in animals had linked changes in gut flora to changes in affective behaviors,” the researchers explained.
Compared to the controls, the women who consumed probiotic yogurt had decreased activity in two brain regions that control central processing of emotion and sensation:
  • The insular cortex (insula), which plays a role in functions typically linked to emotion (including perception, motor control, self-awareness, cognitive functioning, and interpersonal experience) and the regulation of your body's homeostasis, and
  • The somatosensory cortex, which plays a role in your body’s ability to interpret a wide variety of sensations
During the resting brain scan, the treatment group also showed greater connectivity between a region known as the ‘periaqueductal grey’ and areas of the prefrontal cortex associated with cognition. In contrast, the control group showed greater connectivity of the periaqueductal grey to emotion- and sensation-related regions.
The fact that this study showed any improvement at all is remarkable, considering they used commercial yogurt preparations that are notoriously unhealthy; loaded with artificial sweeteners, colors, flavorings, and sugar. Most importantly, the vast majority of commercial yogurts have clinically insignificant levels of beneficial bacteria. Clearly, you would be far better off making your own yogurt from raw milk—especially if you’re seeking to address depression through dietary interventions.

Yes, Your Diet Affects Your Mood and Mental Health

According to lead author Dr. Kirsten Tillisch:34
“Time and time again, we hear from patients that they never felt depressed or anxious until they started experiencing problems with their gut. Our study shows that the gut–brain connection is a two-way street... 'When we consider the implications of this work, the old sayings 'you are what you eat' and 'gut feelings' take on new meaning.'”
The implications are particularly significant in our current era of rampant depression and emotional “malaise.” And as stated in the featured article, the drug treatments available today are no better than they were 50 years ago. Clearly, we need a new approach, and diet is an obvious place to start.
Previous studies have confirmed that what you eat can alter the composition of your gut flora. Specifically, eating a high-vegetable, fiber-based diet produces a profoundly different composition of microbiota than a more typical Western diet high in carbs and processed fats.

The featured research tells us that the composition of your gut flora not only affects your physical health, but also has a significant impact on your brain function and mental state. Previous research has also shown that certain probiotics can help alleviate anxiety:
  • The Journal of Neurogastroenterology and Motility5 reported the probiotic known as Bifidobacterium longum NCC3001 normalized anxiety-like behavior in mice with infectious colitis by modulating the vagal pathways within the gut-brain.
  • Other research6 found that the probiotic Lactobacillus rhamnosus had a marked effect on GABA levels—an inhibitory neurotransmitter that is significantly involved in regulating many physiological and psychological processes—in certain brain regions and lowered the stress-induced hormone corticosterone, resulting in reduced anxiety- and depression-related behavior. It is likely other lactobacillus species also provide this benefit, but this was the only one that was tested.
It’s important to realize that you have neurons both in your brain and your gut -- including neurons that produce neurotransmitters like serotonin. In fact, the greatest concentration of serotonin, which is involved in mood control, depression and aggression, is found in your intestines, not your brain! Perhaps this is one reason why antidepressants, which raise serotonin levels in yourbrain, are often ineffective in treating depression, whereas proper dietary changes often help...

Your Gut Bacteria Are Vulnerable to Your Diet and Lifestyle

Processed, refined foods in general will destroy healthy microflora and feed bad bacteria and yeast, so limiting or eliminating these from your diet should be at the top of your list. Following my recently revised nutrition plan is a simple way to automatically reduce your intake of sugar from all sources. Processed foods wreak havoc on your gut in a number of different ways:
  • First, they are typically loaded with sugar, and avoiding sugar (particularly fructose) is in my view, based on the evidence, a critical aspect of preventing and/or treating depression. Not only will sugar compromise your beneficial gut bacteria by providing the preferred fuel for pathogenic bacteria, it also contributes to chronic inflammation throughout your body, including your brain.
  • Many contain artificial sweeteners and other synthetic additives that can wreak havoc with brain health. In fact, depression and panic attacks are two of the reported side effects of aspartame. Preliminary findings presented at the 65th annual meeting of the American Academy of Neurology also report that drinking sweetened beverages―whether they’re sweetened with sugar or artificial sweeteners—is associated with an increased risk of depression.7
  • Processed foods are also typically loaded with refined grains, which turn into sugar in your body. Wheat in particular has also been implicated in psychiatric problems, from depression to schizophrenia, due to Wheat Germ Agglutinin (WGA), which has neurotoxic activity.
  • The majority of processed foods also contain genetically engineered (GE) ingredients (primarily corn and soy), which have been shown to be particularly detrimental to beneficial bacteria. There are several mechanisms of harm at work here. For example:
    • Eating genetically engineered Bt corn may turn your intestinal flora into a sort of "living pesticide factory," essentially manufacturing Bt-toxin from within your digestive system on a continuing basis
    • Beneficial gut bacteria are very sensitive to residual glyphosate (the active ingredient in Roundup). Due to mounting resistance, GE Roundup Ready crops are being drenched with increasing amounts of this toxic herbicide. Studies have already confirmed that glyphosate alters and destroys beneficial gut flora in animals, as evidenced by the increasing instances of lethal botulism in cattle
    • Recent research also reveals that your gut bacteria are a key component of glyphosate’s mechanism of harm, as your gut microbes have the identical pathway used by glyphosate to kill weeds!
Your gut bacteria are also very sensitive to and can be harmed by:
Antibiotics, unless absolutely necessary (and when you do, make sure to reseed your gut with fermented foods and/or a probiotics supplement)Conventionally-raised meats and other animal products, as CAFO animals are routinely fed low-dose antibiotics, plusgenetically engineered grains, which have also been implicated in the destruction of gut flora
Chlorinated and/or fluoridated waterAntibacterial soap

How to Reseed Your Gut Flora

Considering the fact that an estimated 80 percent of your immune system is located in your gut, reseeding your gut with healthy bacteria is important for the prevention of virtually ALL disease, both physical and mental. The first step is to clean up your diet and lifestyle by avoiding the items listed above. Then, to actively reseed your gut with beneficial bacteria, you’ll want to:
  • Radically reduce your sugar intake. I’m being repetitive here, to drive home the point that you can take the best fermented foods and/or probiotic supplements, but if you fail to reduce your sugar intake you will sabotage your efforts to rebuild your gut flora. This would be similar to driving your car with one foot on the accelerator and one on the brake simultaneously. Simply not a good strategy at all. When you consume sugar at the level of the typical American you are virtually guaranteed to have a preponderance of pathogenic bacteria, yeast and fungi, no matter what supplements you are taking.
  • Eat traditionally fermented, unpasteurized foodsFermented foods are the best route to optimal digestive health, as long as you eat the traditionally made, unpasteurized versions. Some of the beneficial bacteria found in fermented foods are also excellent chelators of heavy metals and pesticides, which will also have a beneficial health effect by reducing your toxic load. Healthy choices include:
    • Fermented vegetables
    • Lassi (an Indian yoghurt drink, traditionally enjoyed before dinner)
    • Fermented milk, such as kefir
    • Natto (fermented soy)
    Ideally, you want to eat a variety of fermented foods to maximize the variety of bacteria you’re consuming. Fermented vegetables, which are one of my new passions, are an excellent way to supply beneficial bacteria back into our gut. And, unlike some other fermented foods, they tend to be palatable, if not downright delicious, to most people.
    As an added bonus, they can also be a great source of vitamin K2 if you ferment your own using the proper starter culture. We tested samples of high-quality fermented organic vegetables made with our specific starter culture, and a typical serving (about two to three ounces) contained not only 10 trillion beneficial bacteria, it also had 500 mcg of vitamin K2, which we now know is a vital co-nutrient to both vitamin D and calcium. Most high-quality probiotics supplements will only supply you with a fraction of the beneficial bacteria found in such homemade fermented veggies, so it’s your most economical route to optimal gut health as well.
  • Take a high-quality probiotic supplement. Although I'm not a major proponent of taking many supplements (as I believe the majority of your nutrients need to come from food), probiotics are an exception if you don’t eat fermented foods on a regular basis.

Nurture Your Gut for Optimal Health and Mental Well-Being

Foods have an immense impact on your body and your brain, and eating whole foods as described in my nutrition plan is the best way to support your mental and physical health.
Mounting research indicates the bacterial colonies residing in your gut may in fact play key roles in the development of brain, behavioral and emotional problems—from depression to ADHD, autism and more serious mental illness like schizophrenia. Certainly, when you consider the fact that the gut-brain connection is recognized as a basic tenet of physiology and medicine, and that there's no shortage of evidence of gastrointestinal involvement in a variety of neurological diseases, it's easy to see how the balance of gut bacteria can play a significant role in your psychology and behavior.
With this in mind, it should also be crystal clear that nourishing your gut flora is extremely important, from cradle to grave, because in a very real sense you have two brains, one inside your skull and one in your gut, and each needs its own vital nourishment.
Cultured foods like raw milk yogurt and kefir, some cheeses, and fermented vegetables are good sources of natural, healthy bacteria. So my strong recommendation would be to make cultured or fermented foods a regular part of your diet; this can be your primary strategy to optimize your body's good bacteria.
If you do not eat fermented foods on a regular basis, taking a high-quality probiotic supplement is definitely recommended. A probiotic supplement can be incredibly useful to help maintain a well-functioning digestive system when you stray from your healthy diet and consume excess grains or sugar, or if you have to take antibiotics.
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